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目的探讨西利宾胺联合甘利欣治疗慢性重度乙肝的疗效。方法将112例慢性重度乙肝患者随机分为治疗组与对照组各56例,治疗组给予西利宾胺200mg1日3次,甘利欣注射液200mg,1日1次。对照组给予奥泰乐15g,1日3次,强力宁注射液200mg,1日1次。肝功正常后,治疗组改甘利欣注射液为甘利欣胶囊150mg,1日3次口服,对照组改强力宁注射液为甘草甜素片150mg,1日3次口服,继续联合用药3个月后停药。治疗前后进行病毒学指标、肝功复常时间以及停药后反跳情况的比较,疗程中比较第2、4周两组间肝功能丙氨酸转氨酶(ALT)、门冬氨酸转氨酶(AST)的均值。结果两组均有效,但治疗组在某些症状、ALT、AST、及其复常时间以及停药后反跳情况、乙肝DNA阴转方面明显优于对照组。结论西利宾胺联合甘利欣是临床治疗慢性重度乙肝的一个理想治疗方案。
Objective To investigate the efficacy of sibidipine combined with glycyrrhizin in the treatment of chronic severe hepatitis. Methods A total of 112 patients with chronic severe hepatitis B were randomly divided into treatment group (56 cases) and control group (56 cases). The treatment group received silybin 200 mg once a day for 3 times and the Glycyrrhizin injection 200 mg once a day. The control group was given Aotai Lok 15g, 3 times on the 1st, powerful Ning injection 200mg, on the 1st. After liver function was normal, the treatment group was changed Gan Lixin injection for the Glycyrrhizin capsule 150mg, on the 1st 3 times orally, the control group to force Li Ning injection of glycyrrhizin tablets 150mg, 3 times on the 1st orally, continue to combination therapy for 3 months After the withdrawal. Before and after treatment of virological indicators, liver function recovery time and the rebound after stopping the comparison, the course of treatment than the first two weeks 2,4 weeks between the two groups of liver function alanine aminotransferase (ALT), aspartate aminotransferase (AST ). Results The two groups were effective, but the treatment group in some symptoms, ALT, AST, and its recurrent time and rebound after stopping the situation, hepatitis B DNA negative conversion was significantly better than the control group. Conclusion Silibin combined with Gan Lixin clinical treatment of chronic severe hepatitis B is an ideal treatment.