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头孢唑啉在健康志愿者中的血药半衰期为1.33h±33min,但在透析病人中其半衰期延长到3.42h±9.18h.因此,在尿毒症病人中使用头孢唑啉可能蓄积而引起神经系统并发症.Schwankhaus等报道过1例革蓝氏阴性菌败血症病人,每6h静脉注入头孢唑啉1g,24h后病人发生神经紧张性阵挛性发作,伴有嗜睡、定向力障碍、运动障碍和多发性肌阵挛.头孢唑啉减量后,48h内病人精神状态改善,神经系统体征消失.Josse等报道1例肾功能衰竭进行血液透析的41岁女性,由于接受静脉内注头孢唑啉33g(3g/d×11d),在透析时观察到病人阵挛发作,一
The half-life of cefazolin in healthy volunteers was 1.33h ± 33min, but its half-life in dialysis patients was extended to 3.42h ± 9.18h. Therefore, the use of cefazolin in patients with uremia may accumulate and cause nervous system Complications .Schwankhaus et al reported a case of gram-negative septic patients, cefazolin 1h intravenously every 6h, 24 hours after the patient had neurocrine clonic seizures, accompanied by drowsiness, disorientation, dyskinesia and multiple Myoclonus cefazolin reduction, within 48h, the patient’s mental status improved, the signs of the nervous system disappeared.Josse et al reported a case of renal failure in hemodialysis 41-year-old female, receiving intravenous cefazolin 33g ( 3g / d × 11d), observed in patients with dialysis clonic seizures, one