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目的:探讨急性重度有机磷中毒通气支持效果。方法:53例急性重度有机磷中毒患者于入院实施气管插管,行通气支持,通气模式选用容量控制或压力控制,加用呼气末正压(PEEP),根据PaO2、PaCO2、呼气末二氧化碳浓度(PetCO2)调整各通气变量参数。清除毒物,给予阿托品,突击氯磷定治疗,适度镇静,营养支持。结果:3例死于心肌缺血,2例放弃治疗,48例治愈(90.57%)。通气支持时间72～156(平均98)h;住院6～15(平均10.5)d,无一例并发症。结论:通气支持对急性重度有机磷中毒患者的救治有效,综合治疗是关键。
Objective: To investigate the effect of ventilation on acute severe organic phosphorus poisoning. Methods: Fifty-three patients with acute severe organophosphorus poisoning were admitted to the hospital with endotracheal intubation. Ventilation was supported. Ventilation mode was selected by volume control or pressure control. Positive end expiratory pressure (PEEP) was used. According to PaO2, PaCO2, end-tidal carbon dioxide Concentration (PetCO2) Adjusts the parameters of each ventilation variable. Remove poison, give atropine, assault chlorothalonidine treatment, moderate sedation, nutritional support. Results: Three patients died of myocardial ischemia, two gave up treatment, and 48 were cured (90.57%). Ventilation support time 72 ~ 156 (average 98) h; hospitalized 6 to 15 (average 10.5) d, no case of complications. Conclusion: Ventilation support is effective in the treatment of patients with acute severe organophosphorus poisoning, and comprehensive treatment is the key.