女贞子提取物及其活性成分齐墩果酸、熊果酸、红景天苷等对去卵巢大小鼠,雌性老龄大鼠均具有抗骨质疏松作用,能抗糖皮质激素引起的或糖尿病并发的骨质疏松以及胶原性关节炎大鼠的骨质破坏。它们的作用机制可能是通过(1)促进成骨细胞分化,抑制基质金属蛋白酶表达,阻滞破骨细胞激活;(2)促进活性维生素D3生物合成以及维生素D受体和钙结合蛋白表达,促进肠钙吸收,抑制尿钙排泄,提高骨密度,产生抗骨质疏松的防治作用。综述了女贞子及其活性成分抗骨质疏松作用的研究进展,为新药研发提供依据。 Fructus Ligustri Lucidi extract and its active ingredient oleanolic acid, ursolic acid, salidroside and other ovariectomized mouse and female rats have anti-osteoporosis, anti-glucocorticoid-induced or diabetic Concomitant osteoporosis and destruction of collagen in rats with osteoarthritis. Their mechanism of action may be through (1) promoting osteoblast differentiation, inhibiting matrix metalloproteinase expression, blocking osteoclast activation; (2) promoting active vitamin D3 biosynthesis and vitamin D receptor and calcium binding protein expression, promoting Intestinal calcium absorption, inhibition of urinary calcium excretion, increase bone mineral density, resulting in the prevention and treatment of osteoporosis. The research progress on the anti-osteoporosis effect of Ligustrum lucidum and its active ingredients was summarized, which provided the basis for the research and development of new drugs.