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目的 :测定复方环丙沙星注射液中环丙沙星和替硝唑的含量。方法 :采用反相 -高效液相色谱法 ,色谱柱C18 柱 ,流动相为0 4mol/L枸橼酸 -甲醇 -乙腈 (2∶1∶0 8) ,流速为0 8ml/min ,检测波长为277nm。结果 :环丙沙星和替硝唑的回收率分别为99 7 %、99 6 % ,RSD分别为0 9 %、0 7 %。结论 :本方法快速、准确 ,可作为该复方制剂的质量控制标准。
Objective: To determine the contents of ciprofloxacin and tinidazole in compound ciprofloxacin injection. Methods: The mobile phase was 0 4mol / L citric acid-methanol-acetonitrile (2:1:08) at a flow rate of 0 8ml / min using reversed-phase high performance liquid chromatography with a C18 column. The detection wavelength was 277nm. Results: The recoveries of ciprofloxacin and tinidazole were 99.7% and 99.6%, respectively, with RSDs of 0 9% and 0 7%, respectively. Conclusion: The method is rapid and accurate and can be used as the quality control standard of this compound preparation.