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为研究运动病的发病机制，采用绕垂直轴交替ｈａ速、减速、旋转刺激等诱发大鼠运动病（ＭＳ）。通过高效液相色谱－电化学检测法测定大鼠旋转刺激前后及旋转刺激后停留０．５ｈ和１ｈ，其间脑和脑干内的单胺类神经递质－去甲肾上腺素（ＮＡ），肾上腺素（Ａ），５－羟色胺（５－ＨＴ）及多巴胺（ＤＡ）的含量。并观察了大鼠接受旋转刺激前后的行为表现。结果表明，大鼠接受１ｈ旋转刺激后，行为表现迟缓，活动减少，对外界刺激不敏感并有排尿排便行为。间脑及脑干内的ＮＡ水平明显下降，Ａ和５－ＨＴ水平明显升高。大鼠脱离旋转刺激后停留０．５ｈ和１ｈ，以上指标都有恢复趋势。特别是停留１ｈ的大鼠，脑内单胺类递质水平基本接近对照组。该结果提示：ＮＡ、Ａ和５－ＨＴ可能是脑内参与ＭＳ发生过程中的重要递质。ＭＳ的发生与应激有关。
In order to study the pathogenesis of motion sickness, rat motion sickness (MS) was induced by alternating ha velocity, deceleration and rotational stimulation around the vertical axis. The contents of monoamine neurotransmitters - norepinephrine (NA), adrenal gland (norepinephrine) and norepinephrine (norepinephrine) in brain and brainstem were measured before and after rotational stimulation and 0.5h and 1h after rotational stimulation respectively by high performance liquid chromatography-electrochemical detection (A), serotonin (5-HT) and dopamine (DA) content. The behavior of rats before and after receiving rotational stimulation was observed. The results showed that rats subjected to 1h rotational stimulation showed slow behavior, decreased activity, insensitivity to external stimuli and urination and defecation. NA levels in the brain and brainstem decreased significantly, A and 5-HT levels were significantly increased. Rats stay out of rotation after 0.5h and 1h, the above indicators have a recovery trend. In particular, rats stay 1h, monoamine neurotransmitter levels close to the control group. The results suggest that NA, A and 5-HT may be important neurotransmitters involved in the development of MS in the brain. The occurrence of MS is related to stress.