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目的探讨糖尿病与Ⅲ期非小细胞肺癌(NSCLC)放射性肺炎的关系。方法回顾性分析绵阳市第三人民医院2012年10月—2016年10月收治的Ⅲ期NSCLC患者150例,根据是否合并糖尿病将所有患者分为对照组100例(未合并糖尿病)与观察组50例(合并糖尿病)。患者均行放射治疗,比较两组患者放射性肺炎发生率,分析血糖控制与放射性肺炎发病的关系及糖尿病病程与放射性肺炎发病的关系。结果观察组患者放射性肺炎发生率高于对照组(P<0.05)。观察组患者中,血糖控制较好与较差患者放射性肺炎发生率比较,差异无统计学意义(P>0.05)。观察组患者中,糖尿病病程≥5年的患者放射性肺炎发生率高于病程<5年的患者(P<0.05)。结论 NSCLC并糖尿病患者放射性肺炎发生风险高于非糖尿病患者。
Objective To investigate the relationship between diabetes and stage Ⅲ non-small cell lung cancer (NSCLC) radiation pneumonitis. Methods A retrospective analysis of Mianyang Third People’s Hospital from October 2012 to October 2016 in patients with stage Ⅲ NSCLC in 150 cases, all patients were divided into control group of 100 patients (without diabetes) and observation group 50 Case (with diabetes). Patients underwent radiation therapy. The incidence of radiation pneumonitis in both groups was compared. The relationship between glycemic control and the incidence of radiation pneumonitis and the relationship between diabetes duration and the incidence of radiation pneumonitis were analyzed. Results The incidence of radiation pneumonitis in observation group was higher than that in control group (P <0.05). There was no significant difference in the incidence of radiation pneumonitis among the observation group patients with better glycemic control and poorer patients (P> 0.05). In the observation group, the incidence of radiation pneumonitis was higher in patients with diabetes ≥ 5 years than in those with <5 years of diabetes (P <0.05). Conclusion The risk of radiation pneumonitis in patients with NSCLC and diabetes is higher than that in non-diabetic patients.