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β2-微球蛋白(β2-MG)是除红细胞和胎盘滋养层细胞以外的有核细胞(特别是淋巴细胞和肿瘤细胞)膜上组织相容性性抗原(HLA)的轻链蛋白组分,随HLA更新降解释放入血,可自由通过肾小球,几乎全部由近曲小管重吸收,正常血清内浓度很低。β2-MG主要由淋巴细胞产生,但肿瘤细胞合成β2-MG的能力非常强。血清β2-微球蛋白可反映肾小球滤过功能受
β2-microglobulin (β2-MG) is a light chain protein component of histocompatibility antigens (HLA) on membranes of nucleated cells (especially lymphocytes and tumor cells) other than erythrocytes and placental trophoblastic cells, With the release of HLA degradation release into the blood, free glomerular, almost all by the proximal tubule reabsorption, the normal serum concentration is low. β2-MG is mainly produced by lymphocytes, but the ability of tumor cells to synthesize β2-MG is very strong. Serum β2-microglobulin can reflect glomerular filtration function by