模拟移动床色谱手性分离甲霜灵外消旋体

来源 :中国化学会第七届全国分子手性学术研讨会 | 被引量 : 0次 | 上传用户：sun763280

【摘要】

：

　　甲霜灵(图1)是一种高效杀菌剂,其杀菌效果主要来源于R-异构体。模拟移动床色谱(SMBC,图2)发展于20 世纪60 年代,通过周期性切换进出口阀的位置来模拟固定相与流动相的逆

【作者】

：

陈韬陈贤铬范军王泰章伟光

【机构】

：

华南师范大学化学与环境学院,广州510006华南师范大学化学与环境学院,广州510006;广州研创生物技术发展有限公司,广州510663

【出处】

：

中国化学会第七届全国分子手性学术研讨会

【发表日期】

：

2015年11期

【关键词】

：

模拟移动床色谱甲霜灵手性拆分操作参数手性固定相

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论文部分内容阅读

　　甲霜灵(图1)是一种高效杀菌剂,其杀菌效果主要来源于R-异构体。模拟移动床色谱(SMBC,图2)发展于20 世纪60 年代,通过周期性切换进出口阀的位置来模拟固定相与流动相的逆流流动而实现组分分离,是一种精确、高效的制备色谱技术[1]。采用SMBC 制备拆分甲霜灵得到光学纯的R-异构体,这对降低农残、环境保护等具有重要意义。

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模拟移动床色谱手性分离甲霜灵外消旋体

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