【摘 要】
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Sleep architecture is often disturbed following a stressful event; nevertheless,the brain circuitry responsible for sleep perturbations by stress has been paid little attention.The lateral septum(LS)h
【机 构】
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Department of Pharmacology,School of Basic Medical Sciences,Fudan University,Shanghai,China
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Sleep architecture is often disturbed following a stressful event; nevertheless,the brain circuitry responsible for sleep perturbations by stress has been paid little attention.The lateral septum(LS)has been shown to have a key role in stress responses and involved in the regulation of cortical activity.However,the exact role of the LS on sleep modulation is not clear.In this study,neuronal activity in LS GABAergic neurons of freely behaving mice was recorded by fiber photometry technology,and chemogenetic and cell-selective lesion approaches were used to identify the essential role of the LS in regulating the sleep-wake behavior.
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