Hepatitis C virus (HCV) hijacks host lipid metabolism for its infection.However, this mechanism remains poorly understood.We previously reported that HCV replication requires hepatocyte nuclear factor
Human lung adeno-carcinoma is one of the most aggressive cancers in the world,with a high incidence and mortality rate.The major obstacle in the field is the late diagnosis due to the highly heterogen
Protein phosphorylation plays a critical role in the regulation of many cellular functions.Analysis of phosphoproteomes by mass spectrometry depends on many factors,in particular an efficient method t
The neural potential of pluripotent neural stem cells (NSCs) makes them a promising source for cell-based therapy of neural tissue damage.However,the exact intracellular molecular mechanisms of neural
Protein acetylation has emerged as a major mechanism in regulating cellular metabolism(1-3).Whereas most glycolytic steps are reversible,the reaction catalyzed by pyruvate kinase is irreversible and t
Of the 20 ribosomally coded amino acid residues,lysine is the most frequently post-translationally modified,which has important functional and regulatory consequences.Here we report the identification
Glycosylation is one of the most important and common forms of protein posttranslational modifications,which is involved in many physiological functions and biological pathways.
CD44 is type-1 transmembrane glycoprotein mediating the response of cells to their cellular microenvironment (1).CD44 proteins participate in many cellular processes,including the regulation of growth
Annonaceous acetogenins are a family of natural products with antitumor activities.The polyether mimic AA005 has recently beenfound to have the ability of inducing cancer cell death via suppression of