DNA polymerase iota is regulated by DNA damage checkpoint controlled JNK/c-Jun signaling and associa

来源 :中国细胞生物学学会2013年全国学术大会 | 被引量 : 0次 | 上传用户：syhlgs

【摘要】

：

Human DNA polymerase iota (polι) possesses error-prone DNA replication features and performs translesion DNA synthesis.It may be specialized and highly regulated in normalmammalian cells;dysregulation

【作者】

：

Jin Yang Fang Yuan Yaqin Huang Jin Yu

【机构】

：

Department of Cell Biology,The Third Military Medical University,Chongqing,China,400038

【出处】

：

中国细胞生物学学会2013年全国学术大会

【发表日期】

：

2013年12期

【关键词】

：

bladder cancer/DNA polymerase iota/JNK signaling/mutagenesis/UV damage

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Acroframosome(AFS)-dependent kinesin motor KIFC1 facilitated acrosomal biogenesis and nuclear shapin

Background:Acrosome formation and nuclear shaping are the main events of spermatogenesis.During the spermiogenesis of the caridean shrimp Exopalaemon modestus,a unique microtubular structure acroframo

会议

KIFC1acroframosomeExopalaemon modestusspermiogenesisacrosome

Myosin 10 is necessary for breast cancer cell invasive growth and metastasis

Invadopodia are specialized actin-based membrane protrusions formed on the ventral surface of invasive cancer cells,and play a key role in ECM degradation and cancer cell invasion.Myosin10 (Myo 10),a

会议

Myosin10invadopodiametastasisPI3K

Ectosome-like vesicles released from the cilium/flagellum carry specific biologically-active protein

It is now well established that primary and motile cilia/flagella can act as cellular antennae,receiving signals from the environment,and that the activated signaling pathways are involved in normal c

会议

proteaseGTPasesporangincell wallChlamydomonas

Dynamics of Focal Adhesions and Reorganization of F-actin in VEGF-Stimulated NSCs under Varying Diff

Precise migration of neural stem/progenitor cells (NSCs) is crucially important for neurogenesis and repair in the nervous system.However,the detailed mechanisms are not clear.

会议

neural stem cells (NSCs)vascular endothelial growth factor (VEGF)directional m

CDK5在TGF-β1诱导的EMT和乳腺癌进程是必需的

上皮-间质转化(EMT)是指具有极性的上皮细胞经过细胞骨架重塑,转换为具有运动能力的间质细胞并获得侵袭和迁移能力的过程,在胚胎发育及癌症进程中发挥重要作用.TGF-β1是一个强有力的EMT诱导因子,在上皮细胞中激活TGF-β1信号通路可以促进EMT的发生.

会议

CDK5TGF-β1EMT乳腺癌

The ErbB2-overexpression tumor metastasis suppression by humanized antibody chA21 with new recogniti

It is widely known that ErbB2 (HER2/p185her2/neu) overexpression in human malignant cancers correlates with poor prognosis and the resistance against radiotherapy,chemotherapy and endocrine therapy.

会议

antibody drugErbB2/Her2trastuzumabchA21breast cancer

Transdifferentiation of lung adenocarcinoma with LKB1 deficiency to squamous cell carcinoma in mice

Lineage transition in different subtypes of non-small cell lung cancer (NSCLC),as implicated by clinical observation of mixed adenocarcinoma (ADC) and squamous cell carcinoma (SCC) pathologies in aden

会议

Adjudin干扰人精子受精能力及其机制

背景:Adjudin系Lonidamine衍生物.以往我们在大鼠、家兔及猎犬研究证明Adjudin是一潜在的男性避孕药,它通过干扰睾丸支持细胞和生精细胞的粘附连接,由此引起成熟前生精上皮精子细胞释放,导致雄性不育(Mruk and Cheng,2011).

会议

Adjudin人精子精子获能受精能力

Smurf1 functions as a thioester bond intermediate-type Nedd8 ligase to promote colorectal cancer

Neddylation is essential for the viability of most model organisms and involved in cancer development.In contrast with more than 600 ubiquitin ligases are known,less than ten Nedd8 ligases have been i

会议

neddylationE3 ligaseNedd8ubiquitinSmurf1colorectal cancer

INMAP Affacts Tumorigenesis Dependently on Its Dosage in Cells

Tumorigenesis relies on the change of protein structure,modification and dosage.Modest protein dosage is indispensable for cellular growth and heredity.On the contrary some protein dosage rising drama

会议

INMAPtumorigenesiscell growthcell cycle

DNA polymerase iota is regulated by DNA damage checkpoint controlled JNK/c-Jun signaling and associa

与本文相关的学术论文