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上皮-间质转化(EMT)是指具有极性的上皮细胞经过细胞骨架重塑,转换为具有运动能力的间质细胞并获得侵袭和迁移能力的过程,在胚胎发育及癌症进程中发挥重要作用.TGF-β1是一个强有力的EMT诱导因子,在上皮细胞中激活TGF-β1信号通路可以促进EMT的发生.
CDK5在TGF-β1诱导的EMT和乳腺癌进程是必需的
【摘 要】
：
上皮-间质转化(EMT)是指具有极性的上皮细胞经过细胞骨架重塑,转换为具有运动能力的间质细胞并获得侵袭和迁移能力的过程,在胚胎发育及癌症进程中发挥重要作用.TGF-β1是一个强有力的EMT诱导因子,在上皮细胞中激活TGF-β1信号通路可以促进EMT的发生.
【作 者】
：
【机 构】
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The Institute of Genetics and Cytology,Northeast Normal University,Changchun 130024,China
【出 处】
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中国细胞生物学学会2013年全国学术大会
【发表日期】
：
2013年12期
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