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Aim: Oxidized low-density lipoprotein (ox-LDL) is a main etiologic factor in atherogenesis, and antioxidants are accepted as effective treatment of atherosclerosis.In this study, the protective effects of corilagin on the oxidative damage of human umbilical vein endothelial cells (HUVECs) caused by ox-LDL and its mechanism were investigated.