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Aim: Muscone is the main active ingredient in ambrette musk which is used to treat angina induced by the reduction of energy and oxygen.The present study aims to investigate the effects of muscone on Ca2+ activity by examining L-type Ca2+ channel (LTCC) and intracellular calcium ([Ca2+]i) in cardiomyocyte in rats, and explore the mechanisms underlying cardio protective effects of ambrette musk.