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The β diketone curcumin and curcuminoids (1,7-diaryl-l,6-heptadiene-3,5-diones) which are a group of naturally occurring 1,3-diketones,possess an antitumor and an antioxidant effect and have a good potential for metal ions complexation.It has been reported that metal complexation alters the various physiological properties especially the cytotoxic and antitumor activities of many naturally occurring compounds.It is demonstrated that the co-ordination of metal ions e.g.Cu(Ⅱ); Mn(Ⅱ); Au(Ⅲ): etc; with bioactive ligands can actually improve the pharmaceutical activity of drugs.