【摘 要】
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Tumor cell resistance is one of the big hurdle limiting the therapeutic efficacy of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-based cancer treatment.Therefore,the development of a
【机 构】
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Department of Chemistry,Jinan University,Guangzhou 510632,China.510632
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Tumor cell resistance is one of the big hurdle limiting the therapeutic efficacy of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-based cancer treatment.Therefore,the development of a safe and effective sensitizer agent is greatly desired for optimizing TRAIL therapy.Herein,we successfully developed a Se/Fe complex with low toxicity to effectively inhibit tumor cells proliferation and migration capabilities through down-regulating ER stress related selenoproteins.Furthermore,it could more efficiently damage tumor spheroids with good penetration capability.More importantly,it could synergize with TRAIL treatment to induce robust ROS generation,down-regulating ER stress related selenoproteins for triggering tumor cells apoptosis in extrinsic and intrinsic signaling pathways.Taken together,this study provides a potential chemo-drug and sensitizer agent to improve the therapeutic efficacy of TRAIL-based cancer treatment.
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