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  5. Iron dysregulation and oxidative stress interact to cause increased amyloid beta production in aged

Iron dysregulation and oxidative stress interact to cause increased amyloid beta production in aged

来源 :2014 International Conference on Aging and Disease(2014年第一届衰 | 被引量 : 0次 | 上传用户：zhhs555
【摘 要】
：
The pathogenesis of sporadic Alzheimers disease (AD) is intimately related to brain aging.Thus, the aged brain especially when metabolically manipulated can be employed as a useful tool to study AD pa
【作 者】
：
Sasanka Chakrabarti Priyanjalee Banerjee Shruti Anand Arghyadip Sahoo Aritri Bir 
【机 构】
：
Department of Biochemistry,Institute of Post-graduate Medical Education and Research,Kolkata,India
【出 处】
：
2014 International Conference on Aging and Disease(2014年第一届衰
【发表日期】
：
2014年7期
【关键词】
：
Brain aging Amyloid beta peptide Amyloid precursor protein Transferrin Ferritin 
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　　The pathogenesis of sporadic Alzheimers disease (AD) is intimately related to brain aging.Thus, the aged brain especially when metabolically manipulated can be employed as a useful tool to study AD pathogenesis.In the present study we have attempted to explore how iron dysregulation is involved in enhanced amyloid precursor protein (APP) and amyloid beta peptide (A β 42) synthesis and accumulation in the aged brain.
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