Small GTP-binding proteins, also known as small GTPases, regulate diverse processes in eukaryotic cells such as signal transduction, cell proliferation, cyt
Interferon (1FN) family is a large group of cytokines involved in innate immune response against various microorganisms.However, whether IFN functions in an
The emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe pulmonary disease in human, and represents the second example of a highly
Hepatocellular carcinoma (HCC) has become the second leading cause of cancer death worldwide.There is a compelling need for novel strategy that will improve
Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type Ⅰ inteferons, which induce the transcription of vari
Iron is an essential nutrient for living cells and is crucial for oxygen transport, cellular respiration, and DNA synthesis.However, the interaction between
Innate antiviral response is critical for host defense against viral infections.Pattern recognition receptors (PRRs) of host cell, such as RIG-like receptor