【摘 要】
：
Aim: To study the therapentic effect of ChaiQingxiaopi Capsule (CQC) on the hyperplasia of mammary glands (HMG) in rats and analyze the possible mechanism in treating HMG.Methods: (1) Seventy rats wer
【机 构】
：
Shanxi Province Academy of Traditional Chinese Medicine, Taiyuan 030012,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: To study the therapentic effect of ChaiQingxiaopi Capsule (CQC) on the hyperplasia of mammary glands (HMG) in rats and analyze the possible mechanism in treating HMG.Methods: (1) Seventy rats were divided into control, model, tamoxifen, Xiaoru Sanjie Capsule, low-, mid-, and high-dose CQC (0.433,0.855, and 1.712 g/kg) groups.After 5 weeks treatment, we measured the height and diameter of nipple, then determined viscera indexes and the levels of estrogen (E2), progestogen (P), prolactin (PRL), testosterone (T), superoxide dismutase (SOD) and malondialdehyde (MDA) in serum; and the pathologic changes in morphology of mammary glands were observed; (2) The acute blood stasis rat model was established with subcutaneous injection of 0.1％ adrenaline hydrochloride and ice water bath.After 1 week treatment, blood was taken from the abdominal artery, and then its blood viscosity and plasma viscosity were measured by blood rheometer; (3) The expression of ERa and PR in mammary gland epithelial cellswas analyzed by immuno-histochemistry.
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