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Nostocflagelliforme is a terrestrial nitrogen-fixing cyanobacterium which is distributed in arid or semiarid steppes in the western and north-western China.N.flagelliforme shows a strong ecological adaptability to xeric drought conditions.2-DE and MALDI-TOF/TOF-MS were conducted to separate and identify differentially expressed levels of antioxidant proteins in N.flagelliforme subjected to desiccation.