15-脂氧合酶别构调控分子设计

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：InsideCSharp

【摘要】

：

脂氧合酶(LOX)是一种含铁的双加氧酶,该家族成员在生物体内专一催化含有顺,顺-1,4-戊二烯结构的多元不饱和脂肪酸(如花生四烯酸和亚油酸)生成相应活性脂质,并在炎症发生和消除中起到重要作用1.上调15-LOX可以促进抑炎因子的生成同时减少促炎因子,是潜在的治疗靶点.此外,15-LOX也在新发现的“铁死亡”过程中起到关键作用,得到各方面的极大关注2.

【作者】

：

陆阳彬李柯楠邓小兵孟虎刘莹来鲁华

【机构】

：

北京大学化学与分子工程学院,分子动态与稳态结构国家重点实验室,100871

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

酶激活剂别构分子理性设计 15-脂氧合酶炎症铁死亡

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15-脂氧合酶别构调控分子设计

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