Overexpression of LDH-A and LDH-B promotes a metastatic phenotype in BT-549 cell

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户:qinlou
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  In 2018,merely breast cancer occupies 30%of all cancers expected to occur in women.However,tumor metastasis is one of the main reasons for poor tumor efficacy,especially for triple-negative breast cancer cell lines(TNBC).Thus,how to find effective biomarkers to track the metastatic development of breast cancer has been a hot topic.
其他文献
Abnormal proliferation of vascular smooth muscle cells(VSMCs)is a common feature of many vascular remodeling diseases.Circular RNA(circRNA)has inextricable connection with various diseases.However,the
Pseudomonas aeruginosa is a Gram negative opportunistic pathogenic bacterium,which causes acute and chronic infections.As the most effective antibiotic for the treatment of multi-drug resistant bacter
Transfer RNAs(tRNAs)are divided into two types according to their variable arm length.The canonical bacterial and eukaryotic cytoplasmic tRNALeu belongs to the type Ⅱ tRNAs with a long variable arm,an
Hippocampus is a traditional medicine in China,which can be used for treating tumors,aging,fatigue,thrombosis,inflammation,hypertension,prostatic hyperplasia and other diseases.1-(5-Bromo-2-hydroxy-4-
In our study,the peptide from Tilapia skin Leu-Ser-Gly-Tyr-Gly-Pro(LSGYGP)presents ACE-inhibitory activity and its IC50 is 61.48 μM by HHL assay.It was found that the LSGYGP exhibiting a mixed inhibit
Osteopontin(OPN)has been identified as a biomarker for tumor progression in many human tumor types.In non-small-cell lung cancer(NSCLC),the tumorigenic functions of OPN are not well understood.The cur
近年来,由于精子质量的下降及男性不育发病率的增加,环境化学物引发的生殖毒性受到广泛关注。二氧化硫(SO2)和砷是两种典型的环境污染物,可同时存在于居民生活区。研究表明,SO2或砷暴露会影响精子发生和男性生殖,但作用机制及其联合效应尚不清楚。
The traditional drug design and discovery methods were time-consuming and expensive,which largely reduced the efficiency of drug design process.Computer-based de novo drug design was applied to accele
In the mammalian immune system,hosts generate a wide variety of antibodies to target foreign molecules.Protein:protein and protein:ligand interaction is an important way to modulate the availability/a
This study investigated the antibacterial effects of the endophytic fungi from Dalbergia odorifera T.Chen and the mechanism on Staphylococcus aureus.JXP25 were isolated from bark of Dalbergia odorifer