【摘 要】
：
BACKGROUND: Liver is the most important metabolic organ for a majority of animals.Therefore, Liver failure,including acute liver injury and chronic liver fibrosis, is a potentially life-threatening st
【机 构】
：
Department of Immunology and Research Center of Basic Medical Science, Tianjin Medical University, C
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
BACKGROUND: Liver is the most important metabolic organ for a majority of animals.Therefore, Liver failure,including acute liver injury and chronic liver fibrosis, is a potentially life-threatening state.Liver transplantation is rec ognized as the only effective treatment for liver failure.However, the big cost, the shortage of donor organs, and the use of immunosuppressive drugs make liver transplantation unavailable for most people.Recent studies have revealed the promising results with mesenchymal stem cell (MSC)-based therapy, which improves various diseases via not only MSCs in oneself but also MSCs-secreted soluble factors.
其他文献
Infectious bronchitis (IB), an acute, highly contagious viral disease of chickens, is caused by infectious bronchitis virus (IBV), a prototype of gammacoronavirus, which has a significant economic imp
猪主要组织相容性复合体(MHC)也叫猪白细胞抗原(SLA),与猪传染性疾病和疫苗引起的免疫应答密切相关.SLA包含3个主要的基因簇(Ⅰ类、Ⅲ类和Ⅱ类).Ⅰ类基因簇包含3个高度多态的经典Ⅰ类基因(SLA-1、SLA-2和SLA-3),形成大量不同的等位基因.SLA Ⅰ类分子的多态性主要集中在α1和α2结构域,二者共同构成抗原肽结合槽.此结合槽是由底部八个折叠层和顶部两个邻近螺旋区组成,且此结合槽可再
Aim of the study: To investigate the effect of euphorbiasteroid on inducing the apoptosis of ilL-60 cells and demonstrate whether the Fas/FasL signaling pathway was involved in the induction of apopto
Aim of the study: To investigate the effect of euphorbiasteroid on inducing the apoptosis of HL-60 cells and identify the role of Bcl-2/Bax signaling pathway in this process.Materials and methods: HL-
研究背景及目的:EBV感染与实体瘤、淋巴瘤和移植后淋巴细胞增殖性疾病(PTLD)等疾病密切相关.利妥昔单抗的使用虽然对EBV感染重型病例取得了一定的疗效,但无效和病情进展的病例仍然不少.由于细胞免疫对于体内控制EBV感染起着重要的作用,过继性免疫治疗具有着令人鼓舞的应用前景.我们的前期研究根据EBV相关疾病的T细胞受体(TCR)谱系优势利用和克隆性具有一定的特异性和倾向性,通过利用EBV抗原肽获得
研究背景及目的:急性淋巴细胞白血病(ALL)具有高度的异质性,不同患者的疗效和预后具有较大的不同.寻找新的与成人ALL预后相关的基因靶标对于指导临床分层治疗以及探讨新的白血病靶向治疗靶点有着重要意义.新近报道HLA-G抗原表达水平与慢性B淋巴细胞白血病预后明显相关,且其临床敏感度较ZAP-70、CD38更高.我们的前期研究也发现急性B淋巴细胞白血病(B-ALL)患者膜结合型HLA-G1基因高表达组
研究背景及目的:新近研究在正常小鼠和肿瘤患者体内发现了具有免疫抑制功能的调节性γδ T细胞(γδTreg),该群细胞属于γδ+T细胞,Foxp3、CD27和CD25表达阳性且能抑制自身CD4+T细胞的增殖.我们前期研究发现粒细胞集落刺激因子(G-CSF)动员可能影响T细胞受体(TCR) Vγ和Vδ亚家族的谱系分布和克隆性,且G-CSF动员后供者TCRVδ1亚家族克隆性的稳定与移植受者移植物抗宿主病
Background: Previously, CD14+HLA-DR1ow/ expression was mainly focus on the solid tumors patients with strong imlow/mune suppressive function.However, whether CD 14+HLA-DR-expression is a prognostic ma
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective way of treating leukemia and other malignant diseases.However, disease recurrence is still the major cause of dea
目的:建立再生障碍性贫血合并铁过载小鼠模型,初步探讨AA与铁过载之间的相互影响.方法:Balb/c小鼠随机分为正常组、AA组、铁过载组和AA合并铁过载组(复合模型组).在末次右旋糖酐铁注射(200mg/kg皮下qw×10次)后的第14天,采用免疫介导的方法(60Co 6.0Gy全身照射后4h内,立即尾静脉输入DBA/2小鼠胸腺细胞1×106个),建立AA合并铁过载的小鼠复合模型,并检测血象、骨髓象