INFLAMMASOME相关论文
目的:对1型糖尿病（T1DM）患者含NLR家族CARD域蛋白4（NLRC4）基因外显子及外显子内含子交界区的罕见变异进行鉴定，并探讨其对基因功能的影......
Pyroptosis is the process of inflammatory cell death.The primary function of pyroptosis is to induce strong inflammatory......
IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota
Inflammasomes and their product interleukin 18 (IL-18) play important roles in gut microbiota monitoring and homeostasis......
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspsde-1, resulting in secretion of ......
The Second Generation of TKI Afatinib Controls Inflammation by Regulating NLRP3 Inflammasome Activat
Objective Chronic inflammation might lead to many malignancies,and inadequate resolution could play a crucial role in tu......
Macrophages reprogrammed by lung cancer microparticles promote tumor development via releasing IL-1β
目的 Despite macrophages are known to contributed for inhibitory immune microenvironment of tumor(tumor associated macro......
目的 1.ToinvestigateserumvitaminDstatusinChineseadultpatientswithbronchiectasis；2.TostudytherelationshipbetweenvitaminDst......
The inflammasomes,which mediate the activation of caspase-1 and maturation of IL-1β and IL-18,has been unambiguously ve......
Expression profile of NLRs and ALR in human colorectal cancer: Correlation with cancer stages and in
Purpose: NLRs (nucleotide-binding domain leucine-rich repeat proteins or NOD-like receptors) are regulators of inflammat......
LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-Ⅰ-
The NLRP3 inflammasome is the most characterized inflammasome activated by cellular infection or stress, which is respon......
P2X7 receptor (P2X7r) is important in inflammation and fibrosis.The aim of the present study was to investigate the effe......
An Essential Role for the NLRP3 Inflammasome in Host Defense against Cryptococcus neoformans infecti
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ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome
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S1PR2 Contributes to Noncanonical Inflammasome Activation and Impairs the Outcome of Escherichia col
Objective: Sepsis is still a threat in hospital with high mortality rates.Absence of the noncanonical inflammasome caspa......
Objective Depression is a pervasive mental disorder and a significant contributor to the global burden of disease,charac......
Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 infl
Subarachnoid hemorrhage(SAH)is a devastating condition with high morbidity and mortality rates due to the lack of effect......
Involvement of tissue transglutaminase-induced inflammasome activation in liver inflammation after S
Background: Liver diseases caused by Schistosoma japonicum(Sj) infection is one of the most serious pathological changes......
Purpose: Abnormal activation of inflammasome is associated with human various diseases, so it is of great significance t......
Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-
Cryptococcus neoformans (C.neoformans) is an opportunistic fungal pathogen which causes Cryptococccosis in immunocomprom......
Enterohemorrhagic Escherichia coil specific enterohemolysin induced IL-1β in human macrophages and E
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N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hem
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Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury throu
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14-Deoxygarcinol,a polyisoprenylated benzophenone from Garcinia cambogia,ameliorates inflammatory re
OBJECTIVE Interleukin(IL)-1β,one of the principal inflammatory cytokines mainly secreted by monocytes and macrophages,i......
Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the func-tions of immune......
TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NL
Nerve agents are used in civil wars and terrorist attacks,posing a threat to public safety.Acute exposure to nerve agent......
In this study,the benzene-induced immunotoxicity associated with NLRP3 inflammasome activation in benzene-induced he......
Autophagy deficiency in myeloid, cells increases susceptibility to obesity-induced inflammasome acti
Autophagy, which is critical for the proper function of organelles such as ER and mitochondria,affects diverse aspec......
Depression is a pervasive mental disorder and a significant contributor to the global burden of disease,characterize......
自身免疫性甲状腺炎(AIT)是一种常见的器官特异性自身免疫性疾病，包括环境、遗传等在内的多种因素参与AIT的发病机制。已知甲状腺从......
Appropriate autophagy has protective effects on ischemic nerve tissue, while excessive autophagy may cause cell death. T......
目的 探讨Nod样受体蛋白(NLRP3)炎症小体对冠状动脉病变程度的预测价值,为NLRP3的临床应用提供依据.方法 以行选择性冠状动脉造影......
核苷酸结合寡聚化结构域样受体3（NLRP3）炎症复合体属于一种常见的模式识别受体，在调节先天免疫和保护性免疫中均发挥重要作用。近年来......
A Novel Mechanism Underlying the Protective Effect of PDE4 Inhibitor Against Cognitive Impairment:In
Background:Inhibition of phosphodiesterase 4(PDE4)improves the leing and memory abilities in Alzheimers disease animal m......
炎性体是一个识别多种固有免疫系统激活物的多蛋白复合体,它可以促进白细胞介素1β(IL-1β)和白细胞介素18(IL-18)等炎症因子的生......
阿托伐他汀具有强效降脂功能,目前已被广泛用于高脂血症和心血管疾病的治疗.此外,阿托伐他汀还能明显抑制白细胞介素1β(IL-1β)、......
炎症小体是一种炎症信号平台，可以识别多种内源性和外源性刺激，介导细胞焦亡的发生和细胞因子的释放。最近的研究表明，炎症小体的激活......
目的:探讨脂多糖(lipopolysaccharide,LPS)联合真菌葡聚糖能否活化支气管上皮细胞16HBE内NOD样受体热蛋白结构域相关蛋白3(Nod-lik......
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and covers a disease sp......
目的探讨严重烫伤大鼠早期心肌组织内NLRP3炎症小体信号通路的表达及意义。方法采用大鼠95℃热水浴18 s，制成40%总体表面积Ⅲ度烫伤......
,Pannexin-1 influences peritoneal cavity cell population but is not involved in NLRP3 inflammasome a
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The inflammasome is an emerging new pathway in innate immune defense against microbial infection or endogenous danger si......
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目的 观察鼠伤寒沙门氏菌不同生长时相鞭毛的表达规律,并研究鞭毛蛋白表达水平与巨噬细胞免疫应答反应的相关性.方法 RT-PCR检测沙......
缺血性卒中是全世界第二大死亡原因及导致成人永久残疾的主要原因。炎性小体在缺血性卒中后的炎症反应中起着关键作用。其中NLRP3......
脑梗死(cerebral infarction，CI)是一种高致残及致死率的缺血性脑血管疾病，炎症反应在其发生和发展中起到了关键的作用。炎性小体是......
