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[期刊论文] 作者：Rui Wang,Hongyang Sun,Haigang Ren,Guanghui Wang,
来源：中国科学:生命科学（英文版） 年份：2020
The presence of intraneuronal Lewy bodies(LBs)and Lewy neurites(LNs)in the substantia nigra(SN)composed of aggregatedα-synuclein(α-syn)has been recognized as...
Role of the C9ORF72 Gene in the Pathogenesis of Amyotrophic Lateral Sclerosis and Frontotemporal Dem
[期刊论文] 作者：Zongbing Hao,Rui Wang,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2020
Since the discovery of the C9ORF72 gene in 2011,great advances have been achieved in its genetics and in identifying its role in disease models and pathological...
[期刊论文] 作者：Dan Wu,Zongbing Hao,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2018
Autophagy is an evolutionarily-conserved self-degradative process that maintains cellular homeostasis by eliminating protein aggregates and damaged organelles.Recently,vesicle-associated membrane protein-associated protein B (VAPB),which is......
[期刊论文] 作者：Kai Fu,Yanfei Wang,Dongkai Guo,Guanghui Wang,Haigang Ren,
来源：神经科学通报（英文版） 年份：2017
Parkinson\'s disease (PD) is the most common neurodegenerative movement disorder.Mutations in the DJ-1,including L166P,are responsible for recessive earlyonset PD.Many lines of evidence have shown that L166P is not only a loss-of-function m......
[期刊论文] 作者：Dongkai Guo,Zheng Ying,Hongfeng Wang,Dong Chen,Feng Gao,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2015
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Poly-PR in C9ORF72-Related Amyotrophic Lateral Sclerosis/ Frontotemporal Dementia Causes Neurotoxici
[期刊论文] 作者：Rui Wang,Xingyun Xu,Zongbing Hao,Shun Zhang,Dan Wu,Hongyang Sun,Chenchen Mu,Haigang Ren,Guanghui Wang,
来源：神经科学通报（英文版） 年份：2019
GGGGCC repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FrD).It has been reported that hexanucleotide repeat expansions in C9ORF72 produce five dipeptide rep......
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