胰岛 β 细胞内质网上的核糖体合成胰岛素原 ,在胰蛋白酶和羧肽酶的作用下分解成胰岛素及C肽。胰岛素从分泌到发挥生物效应的任何环节发生异常 ,包括受体前缺陷 ,如胰岛素分子结构异常、胰岛素原转变为胰岛素不完全和血中存有抗胰岛素物质等。近来 ,有学者提出胰岛素抵抗代谢紊 The ribosomal proinsulin on the beta-cell endoplasmic islet is broken down into insulin and C-peptide by the action of trypsin and carboxypeptidase. Insulin secretion from the biological effects of any part of the occurrence of abnormalities, including pre-receptor defects, such as structural abnormalities in insulin molecules, insulin into incomplete insulin and insulin-resistant substances in the blood and so on. Recently, some scholars have proposed insulin-resistant metabolic disorders