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目的 探索一种适合于小婴儿深低温停循环灌注时的脑保护血气管理策略。方法 2 0例VSD(年龄 2～ 13个月 )婴儿按照不同血气管理和降温速度随机平均分 4组对照 ,脑功能的监测包括 :脑氧代谢参数、生化指标、脑温均匀度的比较及脑电图等。结果 快速降温期采用alpha稳态血气管理脑损害较重 ,在不同降温速度中应用 pH稳态血气管理脑损害均较轻。 结论 小婴儿深低温体外循环快速降温期应用 pH稳态血气管理对改善降温期的脑损害是安全有效的
Objective To explore a cerebral protection blood gas management strategy suitable for infants undergoing hypothermic circulatory arrest. Methods Twenty cases of VSD (age 2 ~ 13 months) infants were randomly divided into 4 groups randomly according to different blood gas management and cooling rate. The monitoring of brain function included: cerebral oxygen metabolism parameters, biochemical indexes, comparison of cerebral temperature homogeneity and brain Electricity and so on. Results In the rapid cooling stage, alpha steady state blood gas management was more severe in brain damage, and pH steady state blood gas management was lesser in different cooling rates. Conclusions The application of steady-state pH-based blood gas management to infant with hypothermic cardiopulmonary bypass during rapid cooling period is safe and effective in improving brain injury during cooling phase