论文部分内容阅读
胞浆型磷脂酶A2(cytosolic phospholipase A2,cPLA2)是一组数量众多的酶。它们能将膜上的磷脂水解为脂肪酸和溶血磷脂。这些脂类的产物可充当细胞内的第二信使,也可进一步代谢成为有效的炎症反应介导物。近年来,越来越多研究表明在冠心病的发病机制及预防性治疗上,cPLA2是一个新的有待研究的因子,可能成为冠心病治疗的新靶点。
Cytosolic phospholipase A2 (cPLA2) is a large group of enzymes. They hydrolyze phospholipids on membranes to fatty acids and lysophospholipids. The products of these lipids act as second messengers in the cell and can be further metabolized into potent mediators of inflammation. In recent years, more and more studies have shown that cPLA2 is a new factor to be studied in the pathogenesis of coronary heart disease and prophylactic treatment, which may become a new target for the treatment of coronary heart disease.