Objective:To evaluate the clinical effects of comprehensive therapy of psychological intervention and rehabilitation training on the mental health of the patients with acute stroke. Methods:A total of 120 patients with acute stroke were randomly divided into trial group and control group.Both groups were given the corresponding drug therapy,medical basic nursing and convention nursing.Besides,psychological intervention and comprehensive rehabilitation training were added to the trial group.SCL-90,Europ stroke scales(ESS) score were assessed with each patient on day 3 for the first time and on day 21 for the second time; Barthel index was assessed on the day 90.Results:After psychological intervention,SCL-90 declined significantly in the trial group comparing with the control group,there were signicant differences in the somatization,obsession,depression,anxiety,fear,ESS score,Barthel index and other psychological factors between the trial group and control group(P<0.05).Conclusions: Comprehensive therapy of early psychological intervention and rehabilitation training can significantly improve the mental health,limb movement function,stress ability and activity of daily living on the patients with acute stroke. Objective: To evaluate the clinical effects of comprehensive therapy of psychological intervention and rehabilitation training on the mental health of the patients with acute stroke. Methods: A total of 120 patients with acute stroke were randomly divided into trial group and control group. given the corresponding drug therapy, medical basic nursing and convention nursing.Besides, psychological intervention and comprehensive rehabilitation training were added to the trial group.SCL-90, Europ stroke scales (ESS) score were assessed with each patient on day 3 for the first time and on day 21 for the second time; Barthel index was assessed on the day 90. Results: After psychological intervention, SCL-90 declined significantly in the trial group comparing with the control group, there were signicant differences in the somatization, obsession, depression, anxiety, fear, ESS score, Barthel index and other psychological factors between the trial group and control group (P <0.05) .Conclusions: Co mprehensive therapy of early psychological intervention and rehabilitation training can significantly significantly the mental health, limb movement function, stress ability and activity of daily living on the patients with acute stroke.