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目的:探讨C反应蛋白(CRP)对于急性白血病化疗后粒细胞缺乏患者感染的诊断价值。方法:选择急性白血病化疗后出现粒细胞缺乏患者64例,按照是否有感染及感染程度分为严重感染组(n=12)、非严重感染组(n=34)及未感染组(n=18),检测感染症状出现24 h内的血常规及CRP。结果:严重感染组CRP显著高于非严重感染组及未感染组,差异有统计学意义(P<0.05);非严重感染组CRP显著高于未感染组,差异有统计学意义(P<0.05);严重感染组中性粒细胞绝对值(ANC)低于非严重感染组及未感染组,但差异无统计学意义(P>0.05);非严重感染组ANC与未感染组比较,差异无统计学意义(P>0.05)。结论:CRP可以作为急性白血病化疗后粒细胞缺乏患者合并感染的检测指标,对于感染程度的判断有较好的辅助作用。
Objective: To investigate the diagnostic value of C-reactive protein (CRP) in patients with agranulocytosis after chemotherapy for acute leukemia. Methods: Sixty-four patients with agranulocytosis after acute leukemia chemotherapy were divided into severe infection group (n = 12), non-severe infection group (n = 34) and uninfected group (n = 18) according to the degree of infection and infection ), Blood tests and CRP within 24 h were detected. Results: The CRP in severe infection group was significantly higher than that in non-severe infection group and non-infected group (P <0.05). CRP in non-severe infection group was significantly higher than that in non-infected group (P <0.05) ); Severe neutrophils absolute neutrophil (ANC) was lower than non-severe infection group and non-infected group, but the difference was not statistically significant (P> 0.05); non-severe infection group ANC and non-infected group, the difference was Statistical significance (P> 0.05). Conclusion: CRP can be used as a marker of co-infection in patients with agranulocytosis after chemotherapy for acute leukemia, which may be helpful to judge the degree of infection.