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本文对１２３例原发性甲状腺功能减退（甲减）患者经甲状腺片替代治疗后Ｔ３、Ｔ４、ＴＳＨ三项监测指标进行了分析，结果提示在甲状腺片治疗过程中Ｔ３反应较为敏感，而Ｔ４对甲状腺片治疗反应较慢，部分病例在治疗过量时Ｔ４仍不能正常，提示在临床甲减甲状腺片治疗中，应以观察ＴＳＨ及Ｔ３变化为主，不能追求Ｔ４正常。用免疫放射法（ＩＲＭＡ）测定的ＴＳＨ由于灵敏度明显提高，在评价甲状腺片替代治疗的效果特别是在判断替代过量方面明显优于放射免疫法（ＲＩＡ）。
In this paper, 123 cases of primary hypothyroidism (hypothyroidism) patients after thyroid replacement therapy T3, T4, TSH three monitoring indicators were analyzed, the results suggest that the treatment of thyroid tablets during T3 response is more sensitive to the T4 Thyroid tablets treatment response is slow, some cases in the treatment of excess T4 is still not normal, suggesting that in the treatment of clinical hypothyroidism tablets should be observed mainly TSH and T3 changes, can not pursue the normal T4. TSH, measured by immunoradiometric assay (IRMA), was significantly better than radioimmunoassay (RIA) in assessing the effectiveness of thyroid replacement therapy, especially in judging surrogate excess, due to the markedly improved sensitivity.