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目的探讨原发性高血压(EH)患者脉压与尿微量白蛋白(UmAlb)早期肾功能损害的相关性。方法对180例原发性高血压患者进行24小时动态血压监测,记录脉压(PP)值,按脉压(>60mmHg与≤60mmHg,1mmHg=0.133kPa)分组,观察两组血尿素氮(BUN)、肌酐(Cr)、尿酸(UA)及尿微量白蛋白(UmAlb)变化及其与脉压值的相关性。结果脉压>60mmHg组UA、UmAlb明显高于脉压≤60mmHg组(P<0.01);偏相关分析显示,UmAlb与收缩压(r=0.315,P<0.05)、脉压(r=0.408,P<0.01)呈正相关。结论脉压值能够很好地反映原发性高血压患者肾脏早期损害,是肾脏早期损害的重要危险因子;脉压大小与尿微量白蛋白严重程度密切相关,定期检测尿微量白蛋白对发现原发性高血压早期肾脏损害有重要的诊断价值。
Objective To investigate the correlation between pulse pressure and early renal dysfunction of urine microalbumin (UmAlb) in patients with essential hypertension (EH). Methods 180 patients with essential hypertension were monitored for ambulatory blood pressure 24 hours. The pulse pressure (PP) was recorded. The pulse pressure (> 60mmHg and ≤60mmHg, 1mmHg = 0.133kPa) ), Creatinine (Cr), uric acid (UA) and urinary microalbumin (UmAlb) and their relationship with pulse pressure. Results UA and UmAlb in pulse pressure> 60mmHg group were significantly higher than those in pulse pressure≤60mmHg group (P <0.01). Partial correlation analysis showed that UmAlb was positively correlated with systolic blood pressure (r = 0.315, P <0.05) <0.01). Conclusion The pulse pressure value can well reflect the early renal damage in patients with essential hypertension and is an important risk factor for early renal damage. The pulse pressure is closely related to the severity of urinary albumin. Urine microalbuminuria Early renal damage to essential hypertension has important diagnostic value.