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通过实验观察乙乙乳膏对实验性损伤性血肿局部软组织炎性介质IL-1β的影响及组织形态学改变。方法:通过打击局部建立家兔急性软组织损伤模型,随机分为乙乙乳膏组,阴性对照组,阳性对照组,正常组。除正常组外各组分别应用乙乙乳膏或对照药或65%酒精局部给药,于治疗后第1、3、5天同一时相局部软组织取材,部分组织匀浆,用ELISA法测定匀浆液中IL-1β含量,在电镜和光镜下观察组织形态学变化。结果:乙乙乳膏组,扶他林凝胶膏组损伤局部软组织瘀血明显消退,肌纤维的修复;盐水组损伤局部软组织IL-1β的含量伤后各时相明显高于正常组(P<0.01);乙乙乳膏组有效抑制模兔损伤局部组织IL-1β的含量(P<0.01),而与扶他林组比较无显著性差异(P>0.05)。结论:乙乙乳膏剂可以有效的促进损伤局部瘀血的消散和肌纤维的修复,其治疗急性软组织损伤的治疗机理与抑制损伤局部软组织炎性因子IL-1β的产生有关。
The effect of EGB cream on IL-1β, an inflammatory mediator of local soft tissues in experimental traumatic hematoma, and histomorphological changes were observed by experiments. Methods: Acute soft tissue injury model was established in rabbits locally and randomly divided into B and C cream group, negative control group, positive control group and normal group. In addition to the normal group each group were administered with ethyl acetate cream or control drug or 65% alcohol local administration, on the 1st, 3rd and 5th days after treatment, the same time, local soft tissue sections, some of the tissue homogenate, measured by ELISA The content of IL-1β in the serous fluid was observed under electron microscope and light microscope. Results: Compared with the normal group, the content of IL-1β in the local soft tissue in the saline group was significantly higher than that in the normal group (P <0.01) (P <0.01), while there was no significant difference (P> 0.05) between the B group and the control group. Conclusion: B cream can effectively promote the dissipation of local blood stasis and repair of muscle fibers, and its therapeutic mechanism for the treatment of acute soft tissue injury is related to inhibiting the production of inflammatory factor IL-1β.