本文利用受体放射配基分析方法观察不同年龄大鼠血小板聚集性、血浆脂质水平及血小板膜LDL受体活性的改变。结果表明,老年大鼠血小板对ADP诱导的聚集反应性明显增强;血浆总胆固醇、低密度脂蛋白胆固醇水平增高;血小板膜LDL受体活性增强,解离常数显著低于对照组。本文作者认为血小板膜受体活性的增强及血浆LDL水平的增高可促进LDL与血小板的结合,提高了LDL对血小板功能的影响,与老年大鼠血小板高反应性改变可能有关。 In this paper, receptor radioligand assay was used to observe the changes of platelet aggregation, plasma lipid and platelet membrane LDL receptor activity in different age rats. The results showed that ADP-induced aggregation reactivity of platelets in aged rats was significantly increased; plasma total cholesterol and low density lipoprotein cholesterol levels were increased; LDL receptor activity of platelet membrane was enhanced and dissociation constant was significantly lower than that of the control group. The authors suggest that increased platelet membrane receptor activity and elevated plasma LDL may promote the binding of LDL to platelets and increase the effect of LDL on platelet function, which may be associated with altered platelet reactivity in aged rats.