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在10年中用固相放射免疫法检测西北地区就诊患者乙肝病毒八项血清标志物16305例,男、女性比例为2.13:1,男性就诊患者乙肝病毒表面抗原(ABsAg),核心抗体(Anti—HBc)的检出率明显高于女性(P<0.005),说明男性的乙肝病毒易感性高于女性。男性乙肝患者的住院率明显高于女性(P<0.005),说明不管所患何种疾病,只要伴有乙肝病毒感染,男性患者的病情一般要重于女性。统计结果还表明,1.男性已肝病毒表面抗原聚合血清白蛋白受体(HBsAg/Re)、e抗原(HBeAg)的检出率高(P<0.005),说明男性患活动性、传染性肝炎多。2.男性患者乙肝病毒核心/IgM抗体(AntiHBc/IgM)、表面抗原/IgM复合物(HBsAG/IgM)的检出率高(P<0.005),说明男性患急性肝炎者多于女性。3.男性患者乙肝病毒表面抗体(Anti—HBs)的检出率明显低于女性(P<0.005),说明男性机体对乙肝病毒的免疫反应性差,预后不良。
In the past 10 years, 16305 serological markers of hepatitis B virus were detected by solid-phase radioimmunoassay in Northwest China. The ratio of male to female was 2.13: 1. The prevalence of hepatitis B virus surface antigen (ABsAg), anti- HBc) was significantly higher in women than in women (P <0.005), indicating that men have a higher susceptibility to hepatitis B than women. The rate of hospitalization for male patients with hepatitis B was significantly higher than that of women (P <0.005), indicating that regardless of the disease, male patients were generally more affected than women, as long as they had hepatitis B virus infection. The statistical results also showed that 1. The detection rate of HBsAg / Re and HBeAg in males was significantly higher (P <0.005), indicating that male patients had active infectious hepatitis many. The prevalence of hepatitis B virus (HBeAg / IgM) and HBsAG / IgM was significantly higher in male patients (P <0.005), which indicated that male patients had more acute hepatitis than female patients. The detection rate of anti-HBs in male patients was significantly lower than that in women (P <0.005), which indicated that the male patients had poor immune response to hepatitis B virus and poor prognosis.