论文部分内容阅读
为探讨SARS患者的CD4 + T淋巴细胞改变与胸部X线表现及临床表现的动态变化关系 ,为SARS的诊断治疗提供相应依据。 (1)通过每天测体温 ,了解热度、热程以及发热规律 ;(2 )入院后行CD4 + T淋巴细胞计数检测 ,此后每隔 2～ 3d进行一次 ;(3)每隔 2 4～ 72h摄胸部正侧位片。结果 2 3例均有发热 ,37 8～ 4 0 1℃。重症患者热程 (12 82± 4 4 9)d ;普通患者为 (7 6 0± 3 14 )d ,(P <0 0 5 )。入院初CD4 + T细胞平均为 17 9%± 5 6 % ;治疗 15～ 30d后为 2 9 4 %± 5 4 %。高峰期CD4 + T细胞最低 12 5 %± 6 2 % ,与其他各期比较 ,差异有显著性意义 (P <0 0 1) ;恢复期 5例肺纤维化患者CD4 + T细胞为2 2 4 %± 4 8% ,较 18例无肺纤维化患者 31 4 %± 4 4 %明显降低 (P <0 0 1) ;5例并发肺纤维化患者恢复时间 (35 8± 12 5 )d ,较 18例无肺纤维化患者 (2 5± 8 6 )d明显延长 (P <0 0 1)。通过CD4 + T细胞和胸部X线的动态观察 ,两者基本呈平行变化 ,但CD4 + T细胞降低较胸部X线改变发生早 ,恢复时间较晚 ,且与肺纤维化的形成有关
To investigate the relationship between the changes of CD4 + T lymphocyte and the dynamic changes of chest X-ray findings and clinical manifestations in patients with SARS and provide the basis for the diagnosis and treatment of SARS. (2) admission CD4 + T lymphocyte count test, and then every 2 ~ 3d once; (3) every 24 ~ 72h photo (1) through the daily test of body temperature to understand the heat, fever and fever; Chest is a lateral film. Results 23 cases were fever, 378 ~ 410 ℃. The severity of severe patients was (12 82 ± 449) days. The average patient was (70 ± 3 14) days (P <0.05). The average admission CD4 + T cells were 17 9% ± 5 6% at admission and 294% ± 54% after 15-30 days of treatment. The peak of CD4 + T cells in the peak period was 125% ± 62%, which was significantly different from other phases (P <0.01). CD4 + T cells in 5 cases of pulmonary fibrosis in recovery period were 224 % ± 48%, which was significantly lower than 31 4% ± 4 4% of 18 cases without pulmonary fibrosis (P <0.01). The recovery time of 5 cases with pulmonary fibrosis was 35 8 ± 12 5 days Eighteen patients without pulmonary fibrosis (25 ± 8 6) d were significantly prolonged (P <0.01). By the dynamic observation of CD4 + T cells and chest X-ray, the two basically showed a parallel change, but the reduction of CD4 + T cells occurred earlier than the chest X-ray, the recovery time was late, and the formation of pulmonary fibrosis