转基因动物是指通过遗传操作 ,使外源基因在体内稳定遗传的动物。转基因动物体系是研究基因功能的新手段 ,在病毒学研究中有广泛的运用前景。越来越多的含有病毒基因、病毒受体基因的转基因小鼠用于病毒与受体、病毒与宿主相互作用和功能的研究 ,从而探讨病毒的致病机理及防治方法。本文就近年来这方面有关问题的现况进行综述 Transgenic animals refer to animals that, through genetic manipulation, inherit foreign genes stably in the body. The transgenic animal system is a new means to study the function of the gene, and has wide application prospects in virological research. More and more transgenic mice that contain viral genes and viral receptor genes are used to study the interaction and function between virus and receptor, virus and host, so as to explore the pathogenic mechanism of the virus and its prevention and cure methods. This article reviews the current status of relevant issues in this area in recent years