目的阐明白细胞介素１受体拮抗剂（ＩＬ１ｒａ）基因多态性对其功能的影响，论证ＩＬ１ｒａ基因型与ＩｇＡ肾病（ＩｇＡＮ）及紫癜性肾炎（ＨＳＰＮ）临床表型之间联系的机理。方法用ＰＣＲ方法对ＩｇＡＮ和ＨＳＰＮ患者ＩＬ１ｒａ基因型进行分析，从ＩＬ１ｒａ不同基因型患者获取外周血单核细胞，观察单核细胞经单核巨噬细胞集落刺激因子（ＧＭＣＳＦ）刺激后，ＩＬ１ｒａ、ＩＬ１α和ＩＬ１β的产生能力。结果无论是ＩｇＡＮ，还是ＨＳＰＮ患者，携带ＩＬ１ｒａ基因ＩＬ１ＲＮ＊２等位基因者其单核细胞ＩＬ１ｒａ的产生能力明显低于不携带该等位基因的个体，而ＩＬ１α和ＩＬ１β的产生能力与是否携带ＩＬ１ＲＮ＊２等位基因无关。结论ＩＬ１ｒａ基因多态性能对其功能产生影响。携带ＩＬ１ＲＮ＊２等位基因者其体内ＩＬ１ｒａ的产生能力存在缺陷。该结果为临床上根据ＩＬ１ｒａ基因型有针对地采取干预治疗奠定了基础。 Objective To clarify the effect of interleukin1 receptor antagonist (IL1ra) gene polymorphism on its function and to demonstrate the relationship between IL1ra genotype and the clinical phenotype of IgA nephropathy (IgAN) and purpuric nephritis (HSPN) The mechanism of contact. Methods PCR method for IgAN and HSPN IL  1ra genotypes were analyzed from IL  1ra patients with different genotypes of peripheral blood mononuclear cells were observed monocytes by monocyte macrophage colony stimulating factor (GM  CSF) After stimulation, IL  1ra, IL  1α and IL  1β production capacity. Results IgAN, or HSPN patients, carrying IL  1ra gene IL1RN * 2 allele of its monocytes IL1ra production capacity was significantly lower than those who do not carry the allele, and IL  1α and IL  1β production capacity and whether to carry IL1RN * 2 allele has nothing to do. Conclusion IL 1ra gene polymorphism can have an impact on its function. IL1RN * 2 allele carrying its body IL 1ra production capacity deficiencies. The results of clinically based IL  1ra genotype targeted interventions and laid the foundation.