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目的探讨敏感的尘肺早期肺纤维化指标。方法采用免疫透射比浊法测定98例Ⅰ期尘肺病患者9、5例X线胸片表现尚不能够诊断为Ⅰ期的0+者及80例无尘肺病对照者血清唾液酸(SA)及铜蓝蛋白(CP)含量。结果Ⅰ期尘肺患者血清SA及CP含量明显高于0+者,0+者血清SA及CP含量明显高于无尘肺对照组,差异均有统计学意义(P<0.01或P<0.05)。结论检测SA和CP含量对尘肺早期肺纤维化程度的估计具有一定的临床意义。
Objective To explore sensitive pulmonary fibrosis indicators of pneumoconiosis. Methods Immuno-turbidimetry was used to detect the serum sialic acid (SA) of 98 patients with stage Ⅰ pneumoconiosis who were not yet diagnosed as stage Ⅰ 0 and those who were non-pneumoconiosis with 9 and 5 cases. Ceruloplasmin (CP) content. Results The levels of SA and CP in patients with stage Ⅰ pneumoconiosis were significantly higher than those in patients with 0+, while the levels of SA and CP in 0 + patients were significantly higher than those without pneumoconiosis (P <0.01 or P <0.05). Conclusion The detection of SA and CP levels in the early stage of pulmonary fibrosis of pneumoconiosis has some clinical significance.