西北国防医学杂志,2015,36(2):101~104.慢性高原病(chronic mountain sickness,CMS)是高原地区常见的一类疾病,其发病机制与高原低氧所引起的高原习服失衡、呼吸驱动减弱、炎性因素,血红蛋白与氧气亲和力下降、促红细胞生成素的合成与释放调节机制紊乱等有关系。该病的患病率以移居者居多,是高原世居者的(5~10)倍,且患病率随海拔高度的升高和生活工作的时间延长而增加。因此,对该病的预防重于治疗。经过多年的临床实践,长期氧疗(LTOT)是防治慢性阻塞性肺疾病(COPD)的有效措施,目前已公认是临床呼 Northwest China Journal of National Defense, 2015,36 (2): 101-104. Chronic mountain sickness (CMS) is a common disease in the plateau. Its pathogenesis is imbalanced with plateau habitat caused by plateau hypoxia, Decreased respiratory drive, inflammatory factors, decreased affinity of hemoglobin and oxygen, and the regulation of erythropoietin synthesis and release mechanisms such as disorders. The prevalence of the disease is mostly migrants, who are (5 to 10) -fold higher than their native counterparts in the plateau. The prevalence increases with increasing altitude and working life. Therefore, the prevention of the disease is more important than treatment. After many years of clinical practice, long-term oxygen therapy (LTOT) is an effective measure to prevent and treat chronic obstructive pulmonary disease (COPD)