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甲型肝炎病毒(HAV)AGM-27株最早从罹患肝炎的非洲绿猴中分离出,似为真正的猿猴株.非洲绿猴、恒河猴和狨猴静脉接种这种病毒后都发生急性肝炎,这可通过血清丙氨酸转氨酶(ALT)和异柠檬酸脱氢酶(ICD)水平升高、组织病理学改变以及抗-HAV阳性得以证实.食蟹猴接种该病毒后并不发生急性肝炎,也许是因为过去接触过HAV,尽管接种后1周可测得高滴度抗-HAV,但只是很小的组织病理学改变,血清肝酶水平仍保持正常.黑猩猩接种大剂量病毒也不出现肝炎症状,但有病毒复制和血清阳转.
Hepatitis A virus (HAV) AGM-27 was isolated from the African monkeys suffering from hepatitis as early as possible, and appears to be a true simian monkey .Acute hepatitis occurs after intravenous inoculation of this virus in African green monkeys, rhesus monkeys and marmoset monkeys , As evidenced by elevated serum levels of alanine aminotransferase (ALT) and isocitrate dehydrogenase (ICD), histopathological changes, and anti-HAV positivity Acute hepatitis did not develop after inoculation of the virus , Perhaps because HAV was exposed in the past, although high titers of anti-HAV were measured one week after vaccination, but only minimal histopathological changes and serum liver enzyme levels remained normal. Symptoms of hepatitis but viral replication and seroconversion.