蛋白激酶Cγ亚型(PKCγ)为PKC家族一员,它能在磷脂酰丝氨酸存在下被钙离子和二酰甘油激活,主要表达于中枢神经系统和外周神经元。PKCγ参与疼痛过敏和转导、海马区长时易化的改变、空间记忆学习和浦肯野细胞运动协调等。PKCγ基因点突变可诱发遗传性色素性视网膜炎、脊髓小脑共济失调和肿瘤等。 Protein kinase C gamma subtype (PKCγ), a member of the PKC family, is activated by calcium and diacylglycerols in the presence of phosphatidylserine and is mainly expressed in the central nervous system and peripheral neurons. PKCγ is involved in pain hypersensitivity and transduction, long-term changes in the hippocampus, spatial memory learning and coordination of Purkinje cell motility. PKCγ gene point mutations can induce hereditary retinitis pigmentosa, spinocerebellar ataxia and tumors.