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分子流行病学资料指出,我国妇女宫颈癌HPV16 DNA同源序列检出率为55.06％,占全部HPV阳性标本的70.83％,提示我国宫颈癌的发生主要与HPV16型感染有关.因此,分离我国HPV16型并研究其生物学功能、致癌特性及其与宫颈癌发生的关系均具有十分重要的意义. 本文作者采用基因克隆手段,以pAt153为载体,从1份来自山西襄垣县宫颈癌高发区宫颈原位癌患
According to molecular epidemiological data, the detection rate of HPV16 DNA homology in Chinese women is 55.06%, accounting for 70.83% of all HPV positive specimens, suggesting that the occurrence of cervical cancer in our country is mainly related to HPV type 16. Therefore, HPV16 Type and to study its biological function, carcinogenicity and its relationship with the occurrence of cervical cancer are of great significance.In this paper, the gene cloning means to pAt153 as a carrier, from a high incidence of cervical cancer Xiangyuan County, Shanxi Province, cervical Cancer bit