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对46例慢性阻塞性肺部疾病(COPD)急性发作期患者作血清和尿磷以及其它电解质、动脉血气分析和肾功能等生化指标测定。其中26例还作血清2、3-磷酸甘油酸(2、3-DPG)、心动图超声等检查。发现低磷血症者14例,占304%;24小时尿磷减少者40例,占870%。左心功能、肾功能、肾磷阈值和2、3-DPG等指标低磷血症组明显低于血磷正常组(P<0.05)。对6例明显低血磷症者给予补磷(KH2PO420mmol/d),补磷后用力肺活量(FVC)比补磷前有明显增加(P<0.05)。探讨了影响COPD急性发作期患者低磷血症或磷缺乏的因素,认为以药物、肾功能、心功能和酸碱平衡紊乱的影响最大。
46 patients with chronic obstructive pulmonary disease (COPD) acute exacerbation of patients with serum and urinary phosphorus and other electrolytes, arterial blood gas analysis and renal biochemical indicators such as determination. 26 cases also made serum 2,3-phosphoglycerate (2,3-DPG), echocardiography and other tests. Found hypophosphatemia in 14 cases, accounting for 30 4%; 24-hour decrease in urine phosphorus in 40 cases, accounting for 87 0%. Left ventricular function, renal function, renal phosphorus threshold and 2,3-DPG and other indicators of hypophosphatemia was significantly lower than the normal phosphorus group (P <0.05). Six patients with obvious hypophosphatemia were given phosphorus (KH2PO420mmol / d), after forced-vital capacity (FVC) was significantly increased before phosphorus supplementation (P <0.05). The factors influencing hypophosphatemia or phosphorus deficiency in patients with acute exacerbation of COPD were discussed, and the most influential factors were drug, renal function, cardiac function and acid-base balance disorders.