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目的 观察高强度聚焦超声热疗前后恶性肿瘤患者血清可溶性白介素 -2受体的变化及意义。方法 采用双抗夹心ELISA法测定 2 7例恶性肿瘤患者热疗前后血清可溶性白介素 -2受体水平。结果 热疗后患者血清可溶性白介素 -2受体水平较治疗前显著降低 (t =2 2 5 ,P <0 0 5 )。结论 高强度聚焦超声热疗后 ,恶性肿瘤患者血清可溶性白介素 -2受体水平降低 ,可能表明恶性肿瘤病人免疫功能的改善
Objective To observe the changes and significance of serum soluble interleukin-2 receptor (IL-2R) in patients with malignant tumor before and after high-intensity focused ultrasound hyperthermia. Methods Serum levels of soluble interleukin-2 receptor (IL-2R) in 27 patients with malignant tumor before and after hyperthermia were measured by double-antibody sandwich ELISA. Results The level of serum soluble interleukin-2 receptor in patients after heat treatment was significantly lower than that before treatment (t = 225, P <0 05). Conclusions After high intensity focused ultrasound hyperthermia, the level of serum soluble interleukin-2 receptor in patients with malignant tumors is decreased, which may indicate the improvement of immune function in patients with malignant tumors