孕激素受体膜组件1(PGRMC1)是近年来新发现的特殊受体,属于膜相关的孕激素受体(MAPR)蛋白家族。PGRMC1介导孕酮(P4)的抗有丝分裂和抗凋亡作用,并参与了颗粒细胞合成甾体激素的过程。在临床上,PGRMC1的异常表达与卵巢早衰(POF)及多囊卵巢综合征(PCOS)相关。本文就PGRMC1对颗粒细胞功能的影响、与卵泡发育的关系以及在人类生殖中的作用展开综述。 Progesterone Receptor Membrane Module 1 (PGRMC1) is a newly discovered special receptor in recent years and belongs to the membrane-associated progestin receptor (MAPR) protein family. PGRMC1 mediates the anti-mitogenic and anti-apoptotic effects of progesterone (P4) and is involved in the process of granulosa cells synthesizing steroid hormones. Clinically, the abnormal expression of PGRMC1 is associated with premature ovarian failure (POF) and polycystic ovary syndrome (PCOS). This article reviews the effects of PGRMC1 on granulosa cell function, its relationship to follicular development, and its role in human reproduction.