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目的 探讨转化生长因子 β1(TGFβ1)在妊高征患者胎盘组织中的表达及其临床意义。 方法 采用免疫组化SABC法检测 64例妊高征患者 (轻度 2 1例 ,中度 2 0例 ,重度 2 3例 )胎盘组织中TGFβ1的表达 ,2 0例正常孕妇为对照组。 结果 ⑴TGFβ1主要表达于胎盘绒毛滋养细胞及蜕膜细胞。⑵妊高征患者胎盘绒毛滋养细胞及蜕膜细胞TGFβ1的表达均明显增高 ,且随病情严重程度的增加而升高。⑶妊高征患者胎盘重量及新生儿体重与胎盘组织TGFβ1呈明显负相关。 结论 胎盘TGFβ1升高引起滋养细胞浸润不足 ,可能是妊高征的发病因素之一。
Objective To investigate the expression of transforming growth factor β1 (TGFβ1) in placenta of patients with pregnancy induced hypertension and its clinical significance. Methods Immunohistochemical SABC method was used to detect the expression of TGFβ1 in 64 patients with PIH (mild 21 cases, moderate 20 cases and severe 23 cases), and 20 normal pregnant women as control group. Results (1) TGFβ1 mainly expressed in placental villi trophoblasts and decidual cells. (2) The expression of TGFβ1 in placental villi trophoblasts and decidual cells in PIH patients were significantly increased, and increased with the severity of the disease. Placental weight and newborn weight in PIH patients were negatively correlated with TGFβ1 in placenta. Conclusion The increase of placental TGFβ1 is caused by insufficient trophoblast infiltration, which may be one of the pathogenesis of PIH.