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目的:观察窄谱中波紫外线(NB-UVB)单独或联合阿维A治疗早期覃样肉芽肿(mycosis fungoides,MF)的疗效。方法:61例I A期~ⅡA期MF患者随机分为两组,其中单纯照射组31例,应用NB-UVB单独照射;联合组30例,NB-UVB照射联合阿维A治疗。结果:61例患者平均治疗时间4个月,单纯照射组31例中,完全缓解11例,部分缓解13例,无效7例;联合组30例中,完全缓解14例,部分缓解12例,无效4例。联合治疗效果显著优于单独治疗,差异有统计学意义(P=0.0305)。联合组30例共接受照射次数729次,人均(24.3±7.5)次,单纯照射组31例共接受照射874次,人均(28.2±6.9)次。两组相比,联合组照射次数少于单纯照射组,差异有统计学意义(P<0.05)。联合组30例人均照射剂量(27.69±13.58)J/cm2,单纯照射组31例人均照射剂量(30.45±11.27)J/cm2,联合组人均照射剂量少于单纯照射组,差异有统计学意义(P<0.05)。两组均未出现严重不良反应。结论:联合治疗用于早期MF,疗效显著,优于单独照射,值得临床推广。
Objective: To observe the efficacy of narrow-band UVB (NB-UVB) alone or in combination with Avia A in the treatment of early mycosis fungoides (MF). Methods: Totally 61 patients with stage Ⅰ A to Ⅱ A MF were randomly divided into two groups. Among them, 31 cases were treated with NB-UVB alone, 30 cases in combination group and NB-UVB combined with Avia A treatment. Results: The mean duration of treatment in 61 patients was 4 months. Among the 31 patients in the irradiation group, 11 were completely relieved, 13 were partially relieved, and 7 were ineffective. Of the 30 patients in the combined group, 14 were completely relieved, 12 were partially relieved, and 12 were ineffective 4 cases. Combination therapy was significantly better than the single treatment, the difference was statistically significant (P = 0.0305). Thirty patients in the combination group received a total of 729 exposure times (24.3 ± 7.5). In the simple irradiation group, 31 patients received a total of 874 exposures, with a mean of 28.2 ± 6.9. Compared with the two groups, the number of irradiation in the combined group was less than that in the pure irradiation group, the difference was statistically significant (P <0.05). Thirty patients in the combined group had a per capita irradiation dose of (27.69 ± 13.58) J / cm 2, and 31 patients in the radiation alone group had a per-capita exposure dose of 30.45 ± 11.27 J / cm 2. The radiation dose in the combination group was less than that in the radiation group alone P <0.05). No serious adverse reactions occurred in either group. Conclusion: Combination therapy for early MF, significant effect, superior to irradiation alone, is worthy of clinical promotion.