一般地认为Graves’病的发病原理可能由于促甲状腺激素样的免疫球蛋白的作用。两个最初被叙述的因子是LATS(Adems ＆ Purves 1956)和LATS-P(Adams ＆ kennedy,1967)。但在许多血清中未能检测出来。可能由于使用的方法不敏感。事实上,一般认为刺激甲状腺免疫球蛋白(TSI)在Graves’病中是刺激人甲状腺的体液因子,这些因子可以通过不同的方法检出:如在甲状腺薄片中,胶质颗粒增加或cAMP的增加(Onaya et Generally believed that the pathogenesis of Graves’ disease may be due to thyroid-stimulating hormone-like immunoglobulin. The two initially described factors are LATS (Adems & Purves 1956) and LATS-P (Adams & Kennedy, 1967). But not detected in many sera. May be insensitive to the method used. In fact, it is generally thought that stimulating thyroid immunoglobulin (TSI) is a humoral factor that stimulates the human thyroid in Graves’ disease and these factors can be detected by different means: as in thyroid slices, glial granules are increased or cAMP is increased (Onaya et